Abstract: Pickering emulsions can be utilized to improve the usage efficiency of water-insoluble drugs as oral drug deliverysystems. The present study showed a series of dopamine-functionalized pectin-based Pickering emulsions foranti-inflammatory medication, The dopamine functionalization induced significant differences in wettability,zeta potential, particle size, and PDI value compared with the oxidized pectin. The resultant Pickering emulsionsconsequently had excellent stability and could be stored for 30 days. Moreover, the morphology of the driedPickering emulsions was all nano-scale spherical particles, Indomethacin (IND) was used as a water-insolubledrug model. The resultant Pickering emulsion-based drug delivery system showed persistent release of IND formore than 12 h, high pH-responsiveness, and biocompatibility, All the results manifested the excellent potentialof dopamine-functionalized pectin-based Pickering emulsions in drug delivery applications, The present workalso provided a new approach to preparing Pickering emulsions from modified anionic polysaccharides fordelivering the water-insoluble drugs.

Keywords:Pectin, Dopamine, Pickering emulsion, Drug delivery system, Indomethacin

Dopamine-functionalized pectin-based Pickering emulsion as an oral drug delivery system.pdf